... Be guided by beauty ... Beauty is an aesthetic. There is beauty in things that work really well — the way a company is run, or the way a theorem comes out. … Don’t give up easily. Stick to something. Not to the point where it’s clearly insane, but be persistent. … Getting fired once can be a good experience. You just don’t want to make a habit of it. … Work with the smartest people you can. Hopefully smarter than you even. It amplifies your effect. … Hire the smartest people you possibly can … Work collaboratively, and let everyone know what everyone else is researching, so people aren’t wasting their time. … You never know where good science is going to take you.